In December 2018, we published an article entitled “Get rid of the jelly invading your brain” which demonstrated the importance of omega-3 fatty acids for maintaining the health of your brain and optimising your cognitive function as you grow older.
This article discussed several key points:
The results of a new study presented at a recent conference show that there is not always optimal incorporation of omega-3 into cell membranes. In certain people, one of the steps in the process - production of the specific fats containing omega-3 - does not take place as it should and it seems these individuals are at higher risk of Alzheimer’s disease. In fact, omega-3 fatty acids do not ‘embed’ directly in cell membranes: they first have to be gathered together with other elements to form phospholipids, the fats which are able to penetrate membranes. And this ‘assembly’ takes place in the liver.
The University of Pennsylvania researchers behind the study showed that in individuals with mild cognitive deficiency or memory problems or who were in the early stages of Alzheimer’s disease, production of some of these phospholipids was defective (notably plasmalogens which are essential for healthy nerve tissue function). What normally happens is that these fats (which contain the precious omega-3) leave the liver to travel to the brain via the blood vessels. But in the above-mentioned cases, the researchers observed unusually low circulating levels of these fats, indicating impaired production in the liver.
According to one of the study’s authors, this decline in production is likely to be age-related: ”as the body ages, the liver can no longer produce enough“. But ageing can be influenced by a number of factors! Conditions such as diabetes and obesity mean the liver has to work harder in order to metabolise fatty acids, which leads to premature ‘fatigue’. In addition, some people are likely to be genetically predisposed to more rapid changes in lipid metabolism in the liver, and these genes are associated with Alzheimer’s disease. In such individuals supplementing with omega-3 is less effective as the liver is unable to use all the precious resources available to it and a proportion of the ingested omega-3 fatty acids never reaches the brain.
These results and their implications open up a totally new field of research in terms of developing nutritional approaches to preventing Alzheimer’s disease and cognitive decline in general. While still supportive of the idea of supplementing with omega-3 (DHA could halve the risk of Alzheimer’s as a result of the renewal of biological membranes (1-2)), they suggest that omega-3 supplementation should be combined with measures aimed at supporting liver function.
There are currently three dietary supplements of particular interest for optimising liver health:
These three natural ingredients thus offer highly-promising ways of supporting liver health, and by extension, boosting cognitive function.
The suggested dose for this combination (to be taken for at least 3 months) is:
2-4 capsules a day of CDP Choline 250 mg.
3 softgels a day of Super Omega-3 at mealtimes.
For those with more risk factors, 3 additional capsules a day of Liver Support Formula.
The study at the centre of this article:
Alzheimer's Association International Conference® 2018 24-Jul-2018 Alzheimer's disease risk impacted by the liver, diet
EPA and DHA: one of the most natural, pure, powerful and stable product on the marketus.supersmart.com
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