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29-09-2015

Nicotinamide riboside: results of first human clinical trial confirm those of animal studies

NAD + Even though this clinical study will not be published for a few months, we can here and now share its extraordinary results: oral supplementation with nicotinamide riboside has been shown to produce a 2.7-fold increase in blood levels of coenzyme NAD+, representing an exceptional advance in anti-ageing!

Nicotinamide riboside, a substance closely related to vitamin B3, is found naturally in trace amounts in various foods such as milk. It is a more potent, ‘no-flush’ version of niacin.

The first human trial conducted on 12 healthy subjects has clearly demonstrated that nicotinamide riboside, at doses of 100mg, 300mg and 1 gram, significantly increases nicotinamide adenine dinucleotide (NAD+) in blood cells. Average maximal increases were approximately 30% at the 100g dose and approximately 50% at the higher doses.
Increases in blood NAD+ were maintained for longer at the higher doses. The results were exactly what the researchers were hoping for – an immediate and long-lasting increase in blood levels of NAD+, as had already been demonstrated in earlier animal studies. .

But why is this significant in terms of anti-ageing?

The older we get, the more our NAD+ levels decrease. An unhealthy lifestyle (over-eating, lack of exercise) can also cause levels to become seriously depleted.
Low levels of NAD+ lead to a decline in mitochondrial health which in turn creates a range of age-related health problems. Likewise, the more NAD+ levels fall, the greater the decrease in activity of sirtuins, a group of enzymes that play a key role in longevity.
Studies conducted on nicotinamide riboside show it to be the most effective precursor at increasing coenzyme NAD+ in cells. By so doing, it improves mitochondrial health and stimulates production of new mitochondria. NAD+ is without doubt the most important cellular cofactor for improving mitochondrial energy production, thus maintaining optimal cell metabolism.

In increasing NAD+, NR supplementation can therefore:
    - improve cellular insulin sensitivity ,
    - stimulate mitochondrial biogenesis,
    - enable more calories to be burned at rest, NAD+ being an essential factor in ATP metabolism. NR supplementation is thus particularly beneficial for those who are overweight.
    - increase fatty acid oxidation and improve muscle performance,
    - protect against oxidative stress,
    - significantly increase sirtuin enzymes thus providing the benefits of a low-calorie diet and physical exercise regime – without following either. It is also one of the most scientifically-supported ways of combatting the effects of ageing, preventing the many diseases associated with mitochondrial decline and increasing animal lifespan, as shown in laboratory tests (and almost certainly human lifespan too).
    - With high bioavailability to the brain, NR may also have neuroprotective effects1 and even offer hope in treating Alzheimer’s disease by improving cognitive function and synaptic plasticity and reducing the formation and toxicity of beta-amyloid plaques in the brain2.
NR supplementation is completely free from toxicity and side-effects, even at doses ten times higher than that shown to be effective. This dietary supplement can therefore be taken by anyone from the age of forty onwards.



1- Chi Y, Sauve AA. Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection. Curr Opin Clin Nutr Metab Care. 2013 Sep 25.
2- Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Sauve AA, Pasinetti GM. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models. Neurobiol Aging. 2013 Jun;34(6):1581-8. doi: 10.1016/j.neurobiolaging.2012.12.005. Epub 2013 Jan 9.
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